Recent Findings from the IDCRP Acute Respiratory Infections Research Area:

Beigel JH, Tebas P, Elie-Turenne MC, Bajwa E, Bell TE, Cairns CB, Shoham S,Deville JG, Feucht E, Feinberg J, Luke T, Raviprakash K, Danko J, O'Neil D, Metcalf JA, King K, Burgess TH, Aga E, Lane HC, Hughes MD, Davey RT; IRC002 Study Team. Immune plasma for the treatment of severe influenza: an open-label, multicentre, phase 2 randomised study. Lancet Respir Med. 2017 Jun;5(6):500-511.

Background: Influenza causes substantial morbidity and mortality despite available treatments. Anecdotal reports sugget that plasma with high antibody titres to influenza might be of benefit in the treatment of severe influenza. 


Fairchok M, Schofield C, Chen WJ, et al. Inverse correlation between 25-OH Vitamin D levels and severity of viral respiratory illness in infants. Journal of Infectious Disease and Epidemiology. 2017, 2(1): 1-7

Background: 25-OH vitamin D levels above 30 ng/mL activate HCAP-18, which impacts the immune response to respiratory viruses. While emerging data suggests a link between low levels of 25-OH vitamin D and an increased incidence of respiratory infections, the relationship between these levels and severity of infection is unknown. We hypothesized that infants with insufficient 25-OH vitamin D levels would have more severe viral respiratory infections.


Powers J, Bacci E, Guerrero, M, et al. Reliability, Validity, and Responsiveness of InFLUenza Patient-Reported Outcome (FLU-PRO©) Scores in Influenza-Positive Patients Evaluation of the performance properties of the Influenza patient-reported outcomes instrument (Flu-PRO) in patients with Influenza-like Illness (ILI). Value in Health.  (In press)  2017


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